HPV-DNA 检验作为治疗后检测方法,一般 CIN II~III 级治疗后 6 月时测定高危 HPV,若
阴性则推荐每年 1 次细胞学检查。也有学者发现,高级别 CIN 患者在治疗后的 10 年内其
浸润癌发生的风险比较高,因而对于高级别 CIN 患者治疗后应每年接受宫颈癌细胞学检
查 1 次,连续 10 年后可恢复到常规筛查;而对于低级别 CIN 患者治疗后分别在第 6、12、24
月接受宫颈癌细胞学检查 1 次,然后恢复到常规筛查。
【参考文献】
1 Naumann RW, Bell MC, Alvarez RD, et al. LLETZ is an acceptable alternative to
diagnostic cold-knife conization[J].Gyneco Oncol, 1994, 55(2):224-228.
2 Gimpelson RJ, Graham B. Using amino cerv after cervical LEEP[J]. J Reprod Med, 1999,
44(3):275-278.
3 Milojkiovic M.Residual and recurrent lesions after conization for cervical intraepithelial
neoplasia grade 3[J]. Int J Gynecol Obstet, 2002, 76(1):49-53.
4 Lapaquette TK, Dinh TV, Hanningan EV, et al. Management of patients with positife
margins after cervical conization[J].Obstet Gynecol, 1993, 82(3):440-443.
5 Johnson N, Khalili M, Hirschwete L, et al. Prechcting resi- dual disease after excision of
cervical dysplasia [J]. Int J Obster and Gynecol, 2003, 110(10):952-955.
6 Wright TC, Cox T, Massad LS, et al. 2001 Consensus guide-lines for the mangagement of
the woman with cervical intraepithelial neoplsia[J]. Am J Obstet Gynecol, 2003, 189(2) : 295-
304.